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Literature summary extracted from

  • Chen, H.; Luo, Q.; Li, H.
    MicroRNA-590-3p promotes cell proliferation and invasion by targeting inositol polyphosphate 4-phosphatase type II in human prostate cancer cells (2017), Tumour Biol., 39, FEHLT .
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.3.66 medicine inositol polyphosphate 4-phosphatase type II is a direct target of microRNA-590-3p. Enforced expression of microRNA-590-3p leads to repression of inositol polyphosphate 4-phosphatase type II messenger RNA and protein expression, as well as upregulation of p-Akt, p-FoxO3a, and cyclin D1 and downregulation of p21 expression in prostate cancer cell lines. Overexpression of inositol polyphosphate 4-phosphatase type II can reduce microRNA-590-3p-induced cell proliferation and invasion as well as tumor growth, and decrease microRNA-590-3p-mediated upregulation of cyclin D1 and downregulation of p21 expression in prostate cancer cells Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.66 Homo sapiens O15327
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.66 22Rv1 cell
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 Homo sapiens
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3.1.3.66 C4-2 cell
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 Homo sapiens
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3.1.3.66 DU-145 cell
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 Homo sapiens
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3.1.3.66 LNCaP cell
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 Homo sapiens
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3.1.3.66 PC-3 cell
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 Homo sapiens
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3.1.3.66 prostate gland
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 Homo sapiens
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3.1.3.66 RWPE-1 cell
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 Homo sapiens
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3.1.3.66 VCaP cell
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 Homo sapiens
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